General Immunology

Research Interests: The Savage lab studies interactions between pathogens, the microbiota, and host. In particular, I currently focus on how the microbiota promotes a heathy colonocyte immunometabolism and how this interaction is altered during disease, putting the host at risk of infection with pathogens and pathobionts. My overall research goal is to understand the basis behind these host-microbiota interactions during health so that host health can be supported with therapeutics during microbial disruption to prevent a loss of colonization resistance.

Research Interests: As a translational scientist, I work with MDs toward clinical trials of immunotherapy. I am scientific director of our Good Manufacturing Practice Facility and director of our cell and gene therapy program. our team works on CAR-T development, manufacturing and delivery in clinical trials.

Research Interests: My research is focused on immunological hurdles in regenerative medicine. Specifically, my lab has determined that some cells may not be immunoprivileged, as previously prescribed by a well-accepted dogma. Hence, my team is assessing the relevance of MHC-I matching in stem cell therapy and musculoskeletal transplantation.

Research Interests: Research Interests: mechanistic understanding of inflammation in chronic diseases; specifically understanding the innate and adaptive immune response in diabetic kidney disease (DKD), and characterizing the role of the immune response on DKD pathogenesis. First group to identify an association between urine complement components and progression of diabetic kidney disease (DKD).

Research Interests: Autoimmunity, Type 1 Diabetes, T cells, Myeloid derived suppressor cells.

Research Interests: Translational research in cross-species phenotype and function of NK cells and NK targeting of cancer stem cells.

Research Interests: Improvement of cancer immunotherapy and development of cancer vaccines.

Research Interests: My research is focused on clinical immunology, neuroimmunology and autoimmunity. The current projects include the immunobiology of neurodevelopmental disorders including autism and schizophrenia. We are also interested in the maternal gestational immune environment and how dysregulation of the maternal immune system impacts offspring development.

Research Interests: Cancer immunotherapy, viral immunology, preclinical modeling.

Research Interests: Our research is focused on understanding the relationship between early life environmental exposures and development of pulmonary disease, such as asthma. We study how mucosal and systemic immunity is established during infancy, and determine the impact of air pollutants, allergens, and infectious disease on childhood lung health.