Comparative Immunology

Research Interests: The Brostoff laboratory develops novel diagnostic tests and vaccines and uses these tools both for clinical application as well as to better study host immune responses to disease. The disease models we are currently studying include feline coronavirus and canine osteosarcoma. We are currently using Raman spectroscopy and machine learning as a platform for novel high-throughput diagnostic test development.

Research Interests: The Savage lab studies interactions between pathogens, the microbiota, and host. In particular, I currently focus on how the microbiota promotes a heathy colonocyte immunometabolism and how this interaction is altered during disease, putting the host at risk of infection with pathogens and pathobionts. My overall research goal is to understand the basis behind these host-microbiota interactions during health so that host health can be supported with therapeutics during microbial disruption to prevent a loss of colonization resistance.

Research Interests: Cancer immune microenvironment and immunotherapy.

Research Interests: My research is focused on immunological hurdles in regenerative medicine. Specifically, my lab has determined that some cells may not be immunoprivileged, as previously prescribed by a well-accepted dogma. Hence, my team is assessing the relevance of MHC-I matching in stem cell therapy and musculoskeletal transplantation.

Research Interests: Dr. Toedebusch is a veterinary neurologist and comparative neuro-oncologist dedicated to improving the lives of humans and dogs with brain tumors. She combines her clinical expertise and scientific training to 1) advance understanding of the translational relevance of spontaneously occurring high-grade glioma as a model for human disease and 2) Uncover the molecular mechanisms of immunosuppression in high-grade glioma. Dr. Toedebusch collaborates with a multidisciplinary team of scientists and physicians to develop and test innovative therapies through clinical trials in canine patients. Her ultimate goal is to discover new treatments for brain tumors that benefit both dogs and humans—advancing care and quality of life across species.

Research Interests: Translational research in cross-species phenotype and function of NK cells and NK targeting of cancer stem cells.

Research Interests: Cancer immunotherapy, viral immunology, preclinical modeling.