Adaptive Immunity

Research Interests: I run clinical trials and an R01 funded basic science lab investigating cancer immunology. I have three overlapping areas of research focus: 1) Mechanisms of resistance to cancer immunotherapy and how to overcome them. 2) Immune modulatory effects of radiotherapy. 3) Influence of obesity and aging on the immune system and how this influences cancer development, progression, and treatment response.

Research Interests: My lab studies the systemic and local of effects of polytrauma on fracture repair with the clinical goal of improving osseous healing in these patients as polytrauma is an independent risk factor for fracture nonunion. We focus on how severe trauma alters the local fracture immune response initially and the longitudinal effects, focusing on the innate and adaptive immune alterations respectively. We use this information to develop therapeutic targets and immunomodulatory treatments.

Research Interests: My research is focused on immunological hurdles in regenerative medicine. Specifically, my lab has determined that some cells may not be immunoprivileged, as previously prescribed by a well-accepted dogma. Hence, my team is assessing the relevance of MHC-I matching in stem cell therapy and musculoskeletal transplantation. Additionally, my laboratory recently initiated a project assessing the immunological function in large-breed dogs affected by systemic and localized fungal mold infections.

Research Interests: mechanistic understanding of inflammation in chronic diseases; specifically understanding the innate and adaptive immune response in diabetic kidney disease (DKD), and characterizing the role of the immune response on DKD pathogenesis. First group to identify an association between urine complement components and progression of diabetic kidney disease (DKD).

Research Interests: HIV immunopathology

Research interests: Our laboratory focuses on the design and application of antibodies and CARs in improving Cancer immunotherapy. We are also interested in identifying regulatory mechanisms in the Cancer-Tumor microenvironment that could interfere with the efficacy of T-cell-based immunotherapy.

Research Interests: Improvement of cancer immunotherapy and development of cancer vaccines.

Research Interests: Cancer immunotherapy, viral immunology, preclinical modeling.

Research Interests: T cell responses to Salmonella and Chlamydia

Research Interests: Focusing on how bidirectional communication between the nervous and immune system alters immune outcomes in gut and lung.